Status:
TERMINATED
Effectiveness of Bronchodilator Nebulization With and Without Noninvasive Ventilation in COPD
Lead Sponsor:
National University Health System, Singapore
Conditions:
Chronic Obstructive Pulmonary Disease (COPD)
Type 2 Respiratory Failure
Eligibility:
All Genders
21-99 years
Phase:
NA
Brief Summary
The study aim to evaluate effectiveness of two bronchodilator nebulization strategies in patients with acute decompensated type 2 respiratory failure due to acute exacerbation of chronic obstructive p...
Detailed Description
Decompensated type 2 respiratory failure during acute exacerbation of chronic obstructive pulmonary disease (COPD) is treated with non-invasive ventilation (NIV) and nebulized bronchodilators. Nebuliz...
Eligibility Criteria
Inclusion
- Age ≥21 years.
- Known or suspected COPD (defined by a ratio of Forced Expiratory Volume in 1 second (FEV1) to Forced Vital Capacity (FVC) of less than 0.7).
- Acute decompensated type 2 respiratory failure (ABG pH ≤ 7.35 and PaCO2\>45mmHg).
- Clinical decision made to start NIV.
Exclusion
- Other acute decompensated type 2 respiratory failure related conditions (e.g. neuromuscular, heart failure etc.).
- Pneumonia present in the chest radiograph.
- Other conditions which may change lung impedance (e.g. heart failure or lung fibrosis).
Key Trial Info
Start Date :
April 10 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 12 2020
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT03481543
Start Date
April 10 2018
End Date
November 12 2020
Last Update
October 13 2022
Active Locations (1)
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1
National University Hospital
Singapore, Singapore