Status:
COMPLETED
The Effect of Pregabalin Given Preoperatively on the Tourniquet Induced Ischemia-reperfusion
Lead Sponsor:
Baskent University
Conditions:
Ischemia Reperfusion Injury
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The application of tourniquet is indispensable for a bloodless surgical area in total knee arthroplasty surgery. The release of tourniquet produces reactive oxygen species which can cause injury and t...
Detailed Description
Investigators will randomize patients into two groups. 1) Pregabalin group 2) Control group. Investigators will give orally pregabalin 150 mg to the pregabalin group patients two times (first dose 1 ...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists (ASA) physical status I-II
- Undergoing a total knee arthroplasty surgery
- Accept neuroaxial anesthesia for surgery
Exclusion
- Any antiepileptic drug use
- Allergic reaction to pregabalin
- Severe hepatic, renal or gastrointestinal disorders
- Psychiatric disorders
- Pregnant women or breastfeeding
- NSAID or opioid drug use for a long time
- Diabetic or other neuropathic pain
Key Trial Info
Start Date :
October 10 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 15 2018
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT03482544
Start Date
October 10 2018
End Date
November 15 2018
Last Update
November 19 2018
Active Locations (1)
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1
Baskent University
Konya, Turkey (Türkiye)