Status:
WITHDRAWN
Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery
Lead Sponsor:
University of Sao Paulo
Conditions:
Circulatory Shock
Non-cardiac Surgery
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of the present study is to evaluate the effect of vasopressin compared to norepinephrine on the clinical complications of patients with vasospastic shock after noncardiac surgeries.
Detailed Description
The Systemic Inflammatory Response Syndrome (SIRS) is a common complication after non-cardiac surgery, impacting negatively on patient outcome and with high incidence rates. Vasoplegic syndrome is the...
Eligibility Criteria
Inclusion
- Age greater than 18 years;
- Patients undergoing high-risk non-cardiac surgery;
- vasopressor need within 24 hours after surgery, defined as mean arterial pressure (MAP) \<65 mmHg after volume resuscitation with at least 1 liter of crystalloid solution (Ringer's lactate) and maintaining a cardiac index\> 2.2 ml / min / m²;
- Signature of the informed consent form.
Exclusion
- Allergy to vasoactive drugs;
- Previous use of vasopressor;
- Gestation;
- Presence of Raynaud's phenomenon, altered Allen's test, systemic sclerosis or vasospastic diathesis;
- Severe hyponatremia (Na \<130 mEq / L);
- Acute mesenteric ischemia;
- Acute coronary syndrome;
- Participation in another study;
- Refusal to participate in the study.
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 2 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03483753
Start Date
January 1 2019
End Date
October 2 2023
Last Update
October 5 2023
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.