Status:
COMPLETED
Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section
Lead Sponsor:
Assiut University
Conditions:
Pruritus
Eligibility:
FEMALE
20-40 years
Phase:
PHASE2
Brief Summary
Neuraxial anesthesia, which includes epidural anesthesia and intrathecal anesthesia, is a frequent anesthetic approach for caesarean delivery and other lower abdominal and lower limb anesthetic proced...
Detailed Description
The study will be carried on 40 parturients scheduled for elective cesarean section (CS) under intrathecal anesthesia. They will be randomly allocated into two equal groups of 20 parturients each: Gr...
Eligibility Criteria
Inclusion
- Parturients of American Society of Anesthesiologists (ASA) class I or II physical status.
- Age: 20-40 years.
- At term gestation (≥ 37 weeks) with a singleton uncomplicated pregnancy.
- Elective cesarean delivery under intrathecal anesthesia.
Exclusion
- Parturient refusal.
- Significant organ dysfunctions (e.g., cardiac, respiratory, renal, or liver disorders).
- Morbid obesity (BMI \>35).
- Parturients with known hypersensitivity to granisetron, morphine or amide local anesthetics.
- Parturients with pruritogenic systemic disease.
- A coexisting skin disorder or preexisting pregnancy induced pruritus.
- Parturients with any contraindication for intrathecal anesthesia, e.g. coagulopathy.
- Emergency cesarean section.
- Psychiatric disorders.
- Fetal abnormalities.
- Failed or unsatisfactory intrathecal block.
Key Trial Info
Start Date :
June 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 30 2020
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03483870
Start Date
June 1 2018
End Date
October 30 2020
Last Update
September 9 2021
Active Locations (1)
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1
Assiut University Hospital
Asyut, Egypt