Status:
COMPLETED
The Relationship Between Microsatellite Instability and Efficacy of Fluorouracil Based Adjuvant Chemotherapy in Gastric Cancer After Operation
Lead Sponsor:
Affiliated Hospital of Qinghai University
Collaborating Sponsors:
Qinghai People's Hospital
LanZhou University
Conditions:
Gastric Cancer
Eligibility:
All Genders
18-80 years
Brief Summary
The relationship between Microsatellite instability and efficacy of fluorouracil based adjuvant chemotherapy in gastric cancer after operation.
Detailed Description
To explore the relationship between Microsatellite instability and efficacy of fluorouracil based adjuvant chemotherapy in gastric cancer after operation.
Eligibility Criteria
Inclusion
- Histopathology or cytopathology proven gastric cancer;
- Operable advanced gastric cancer patients: primary lesions can be completely excision, no distant metastasis;
- Postoperative patients who can tolerate 5-FU based (5-FU，S-1 or Capecitabine) adjuvant chemotherapy;
- Life expectancy of at least 6 months;
- ECOG（Eastern Cooperative Oncology Group ） score 0-1;
- Age: 18\~80 years old;
- Normal hemodynamic indices before the recruitment (including blood cell count and liver/kidney function).
- For example: WBC（White blood cell count ）\>4.0×109/L; NEU（Neutrophils）\>1.5×109/L; PLT（Platelet）\>100×109/L;
- Roughly normal cardiopulmonary function: No coronary heart disease, myocardial infarction, pulmonary heart disease, refractory hypertension;
- Not concomitant with other uncontrollable benign diseases before the recruitment;
- 9\. Voluntarily signed the informed consent.
Exclusion
- Advanced gastric cancer patients with distant metastasis and inoperable ;
- Patients who cannot tolerate 5-FU based adjuvant chemotherapy;
- Pregnant or lactating women;
- Patients who have no desire to participate in the study.
Key Trial Info
Start Date :
March 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2021
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT03485196
Start Date
March 1 2017
End Date
April 1 2021
Last Update
August 10 2022
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
The Second Hospital Affiliated to Lanzhou University
Lanzhou, Gansu, China
2
Qinghai University Affiliated Hospital
Xining, Qinghai, China, 810000
3
People's Hospital of Qinghai Province
Xining, Qinghai, China