Status:
COMPLETED
Interaction Diaphragm and Cardiac Function During Ventilator Weaning
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Ventilator Weaning
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Weaning failure is associated with prolonged duration of mechanical ventilation that itself can worsen patient's prognosis. Therefore, identification of the causes and mechanisms leading to weaning fa...
Detailed Description
The study will take place in the Medical ICU of Pitié-Salpêtrière Hospital in Paris. The ICU have an established and successful clinical research program and infrastructure. ICU patients will be enro...
Eligibility Criteria
Inclusion
- Patients adult (age ≥ 18 years)
- Intubation and invasive mechanical ventilation longer than 48 hours;
- Failure to the first spontaneous breathing trial;
- Presence of weaning readiness criteria
- Oral informed consent
- Patient with affiliation to the french healthcare system
Exclusion
- Pregnant women
- Patient opposition
- Contraindication to perform magnetic phrenic nerves stimulation technique (chest tube, cardiac pacemaker or implanted defibrillator, cervical implants, chest drains,...)
- Impossibility to consider ventilator weaning (total ventilator dependence : preexisting neuromuscular disorders, cervical spine injury…)
Key Trial Info
Start Date :
April 27 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 19 2019
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT03486249
Start Date
April 27 2018
End Date
July 19 2019
Last Update
March 2 2021
Active Locations (1)
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1
Groupe Hospitalier Pitié-Salpétrière
Paris, France, 75013