Status:
TERMINATED
Taxonomic and Functional Composition of the Intestinal Microbiome: a Predictor of Rapid Cognitive Decline in Patients With Alzheimer's Disease
Lead Sponsor:
Nantes University Hospital
Conditions:
Alzheimer Disease
Intestinal Microbiota
Eligibility:
All Genders
70-90 years
Phase:
NA
Brief Summary
The objective of the study is to highlight a modification of the composition of the intestinal microbiota associated with the diagnosis of Alzheimer's disease and its most unfavorable form, Rapid Cogn...
Eligibility Criteria
Inclusion
- For Alzheimer groups without DCR and Alzheimer with DCR:
- patients between 70 and 90 years old
- with mild to moderate Alzheimer's disease (MMSE\> 15/30),
- followed in the CMRR of the University Hospital of Nantes or Angers
- having given their informed consent
- For the control group (non-Alzheimer's)
- more patients between 70 and 90 years
- consultant for a subjective memory complaint isolated at the CMRR of Nantes or Angers University Hospital,
- having given their informed consent
Exclusion
- Major patients under tutorship, curatorship or safeguard of justice
- Cognitive disorders possibly related to a metabolic or psychiatric cause
- History of prescription of antibiotic treatment in the last month
- History of acute gastrointestinal illness in the last month
- History of hospitalization for an acute medical pathology or for a surgical procedure in the last month
Key Trial Info
Start Date :
September 4 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 12 2023
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT03487380
Start Date
September 4 2017
End Date
June 12 2023
Last Update
February 1 2024
Active Locations (2)
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1
CHU de Angers
Angers, France, 49000
2
CHU de Nantes
Nantes, France, 44000