Status:
COMPLETED
Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma
Lead Sponsor:
Fakultas Kedokteran Universitas Indonesia
Conditions:
Melasma
Eligibility:
FEMALE
21-64 years
Phase:
PHASE3
Brief Summary
This study assess the effectiveness of oral tranexamic acid in combination with hydroquinone cream in the treatment of melasma.
Detailed Description
Hydroquinone (HQ) is considered the gold standard depigmenting agent for melasma, nevertheless, many patients are recalcitrant to this treatment. Recent studies have shown that tranexamic acid, a pla...
Eligibility Criteria
Inclusion
- moderate melasma (subject with mMASI score of 5 to 7.9),
- severe melasma (subject with mMASI score ≥ 8),
- willing to follow up for 6 months.
Exclusion
- pregnant women,
- nursing women,
- women on exogenous hormones
- current treatment with blood thinners,
- had a history of thrombosis,
- had an abnormal kidney function,
- use of topical hydroquinone within 3 months of study enrollment,
- use of topical steroids, vitamin A analogs, chemical peels within 1 month of study
Key Trial Info
Start Date :
March 16 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 2 2017
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03751163
Start Date
March 16 2016
End Date
April 2 2017
Last Update
November 26 2018
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