Status:
COMPLETED
In Vitro Model of the Cystic Fibrosis Bronchial Epithelium Via iPS Technology
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
18+ years
Brief Summary
In order to further enable physiopathology studies, the aim of this project is to validate an in vitro model of cystic fibrosis created using induced pluripotent stemcell (iPS) differentiated bronchia...
Detailed Description
The investigator's primary objective is to generate iPS lines from 3 CF patients and from 3 healthy subjects. Secondary objectives include verification that cell lines express the CFTR gene according...
Eligibility Criteria
Inclusion
- Inclusion Criteria for subjects with Cystic Fibrosis:
- Homozygote for the p.Phe508del mutation
- Signed informed consent given by the subject
- Inclusion Criteria for subjects without Cystic Fibrosis:
- Signed informed consent given by the subject
- Exclusion Criteria:
- Pregnancy, breastfeeding
- Participant in an exclusion period determined by a previous study
- Participant under any kind of guardianship
- Unaffiliated with or not a beneficiary of a social security program (health insurance)
- Subject deprived of liberty (e.g. prisoners)
- Subject with positive infectious markers for HIV1, HIV2, HBC or HBV
- Exclusion Criteria for subjects with Cystic Fibrosis:
- Any pathology requiring a treatment or a pathology not requiring treatment but with clinical significance according to the investigator
Exclusion
Key Trial Info
Start Date :
November 5 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 25 2019
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT03754088
Start Date
November 5 2018
End Date
April 25 2019
Last Update
September 26 2022
Active Locations (1)
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1
Hôpital Arnaud de Villeneuve - CHU de Montpellier
Montpellier, France, 34295