Status:
UNKNOWN
Effect of Ascorbic Acid on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery
Lead Sponsor:
Xuzhou Medical University
Conditions:
Postoperative Pulmonary Complications
Eligibility:
All Genders
18-60 years
Phase:
EARLY_PHASE1
Brief Summary
Postoperative pulmonary complications(PPCs) including, but not limited to ,hypoxemia, pneumonia, ventilator-induced lung injury, and acute respiratory distress syndrome (ARDS),atelectasis,pleural effu...
Detailed Description
The possible mechanisms of ascorbic acid to alleviate ischemia-reperfusion injury are as follows: 1 Ascorbic acid as a first-line antioxidant in plasma can reduce stress by eliminating excess Reactive...
Eligibility Criteria
Inclusion
- Age between 18-60 years old
- Selective cardiac surgery under cardiopulmonary bypass
Exclusion
- Emergency surgery
- Previous cardiac surgery
- Severe lung disease
- BMI\<18 or \>30
- Mean pulmonary arterial pressure \>40 mmHg
- were allergic to ascorbic acid
Key Trial Info
Start Date :
December 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2019
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT03756727
Start Date
December 1 2018
End Date
July 1 2019
Last Update
November 28 2018
Active Locations (1)
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1
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China