Status:
UNKNOWN
Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty (THA)
Lead Sponsor:
Hvidovre University Hospital
Collaborating Sponsors:
Kehlet, Henrik, M.D., Ph.D.
Conditions:
Orthostatic Intolerance
Orthostatic Hypotension
Eligibility:
All Genders
18-65 years
Brief Summary
Incidence and pathophysiologic hemodynamics of orthostatic intolerance and orthostatic hypotension in patients undergoing unilateral THA
Detailed Description
Early postoperative mobilization is a cornerstone in the so-called fast track multimodal perioperative approach and is essential in preventing postoperative morbidity and reducing hospital length-of-s...
Eligibility Criteria
Inclusion
- Age 18-65
- Written informed consent
- Patients that speak and understand Danish
- Patients undergoing primary unilateral total hip arthroplasty in spinal anesthesia in standardized fast-track setting
Exclusion
- Alcohol and drug abuse
- Cognitive dysfunction
- History of orthostatic hypotension
- Use of anxiolytic or antipsychotic drugs
- Use of opioids
- Use of following vasodilator antihypertensive drugs: beta-blockers, angiotensin converting enzyme inhibitors (ACEI), angiotensin 2 receptor blockers (ARBs), calcium channel blockers
- Use of loop diuretics, thiazid diuretics and potassium-sparing diuretics
- Use of Gabapentin
- Arrhythmias or heart failure
- Diabetes mellitus type I
- Diabetes mellitus type II
- History of following diseases in the autonomic nervous system: Parkinson disease, multiple sclerosis, autonomic neuropathies
- History of cerebral apoplexy or transitory cerebral ischemia
- Dementia
- American Society of Anesthesiologists (ASA) score ≥ 4
Key Trial Info
Start Date :
March 18 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 15 2021
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT03759574
Start Date
March 18 2019
End Date
May 15 2021
Last Update
January 28 2020
Active Locations (1)
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1
Hvidovre Hospital
Copenhagen, Denmark