Status:
RECRUITING
Collagen Cross-linking in Keratoconus
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Eye Institute (NEI)
Conditions:
Keratoconus
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with ke...
Detailed Description
In the U.S., CXL and topography-guided laser ablation were approved independently, but not together. Another variation in technique involves the use of mitomycin-C (MMC), which is effective in reducin...
Eligibility Criteria
Inclusion
- Diagnosis of keratoconus
- Minimum corneal thickness of 410 microns
Exclusion
- Inability to maintain fixation for OCT imaging
- Inability to commit to required study visits
- Inability to give informed consent
- Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery
- Mature cataracts if found to limit visual potential to worse than 20/40
Key Trial Info
Start Date :
June 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03760432
Start Date
June 20 2018
End Date
December 1 2027
Last Update
September 9 2025
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239