Status:
UNKNOWN
Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Collaborating Sponsors:
Comisión Nacional de Investigación Científica y Tecnológica
Conditions:
Septic Shock
Hyperlactatemia
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Persistent hyperlactatemia has been traditionally considered as representing tissue hypoxia, and lactate normalization is recommended as a resuscitation target by the Surviving Sepsis Campaign (SSC). ...
Detailed Description
GENERAL OBJECTIVE To demonstrate that a CRT-targeted FR is associated with less positive fluid balances, organ dysfunctions, and similar improvement of markers of tissue hypoperfusion and hypoxia, whe...
Eligibility Criteria
Inclusion
- Septic shock diagnosed at ICU admission according to the Sepsis-3 Consensus Conference \[35\], basically septic patients with hypotension requiring norepinephrine (NE) to maintain a mean arterial pressure (MAP) of 65 mmHg, and serum lactate levels \> 2 mmol/l after initial fluid resuscitation.
- Less than 24 h after fulfilling criteria for septic shock
- Positive fluid responsiveness assessment
Exclusion
- 1\. Pregnancy
- Anticipated surgery or dialytic procedure during the first 6h after septic shock diagnosis
- Do-not-resuscitate status
- Child B or C liver cirrhosis
- Active bleeding
- Severe concomitant acute respiratory distress syndrome (ARDS)
Key Trial Info
Start Date :
June 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2019
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT03762005
Start Date
June 1 2018
End Date
December 31 2019
Last Update
December 3 2018
Active Locations (1)
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1
Pontificia Universidad Catolica de Chile
Santiago, Santiago Metropolitan, Chile, 7500000