Status:
ACTIVE_NOT_RECRUITING
Additional Treatments to the Local Tumour for Metastatic Prostate Cancer: Assessment of Novel Treatment Algorithms
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Wellcome Trust
Conditions:
Prostate Cancer
Metastatic Prostate Cancer
Eligibility:
MALE
18+ years
Phase:
PHASE2
Brief Summary
Local cytoreductive treatments for men with newly diagnosed metastatic prostate cancer in addition to standard of care treatment
Detailed Description
TITLE: Additional Treatments to the Local tumour for metastatic prostate cancer: Assessment of Novel Treatment Algorithms (ATLANTA) OBJECTIVES: To determine whether the addition of local treatment to...
Eligibility Criteria
Inclusion
- Diagnosed with prostate cancer within 6 months of screening visit
- Metastatic disease (Any T, Any N, M1+) of any grade, stage or Prostate Specific Antigen (PSA) level.
- Fit to undergo standard of care treatment for metastatic disease and both minimally invasive therapy and prostate radiotherapy/prostatectomy.
- Performance status 0-2
- Histologically proven local tumour
Exclusion
- Patient did not undergo and/or is unable to undergo standard of care baseline imaging tests for confirmation of metastatic status (CT abdomen/pelvis AND chest Xray (or CT chest) AND radioisotope bone scan (or whole body imaging such as MRI or PET imaging as alternative to all preceding scans mentioned here) AND prostate MRI.
- Prior exposure to long-term androgen deprivation therapy or hormonal therapy for the treatment of prostate cancer unless started within 6 months of screening visit.
- Prior chemotherapy or local or systemic therapy for treatment of prostate cancer (apart from ADT or hormonal therapy as outlined above)
Key Trial Info
Start Date :
April 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2027
Estimated Enrollment :
433 Patients enrolled
Trial Details
Trial ID
NCT03763253
Start Date
April 10 2019
End Date
January 31 2027
Last Update
February 7 2025
Active Locations (21)
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1
Wirral University Teaching Hospital, Wirral University Teaching Hospital NHS Foundation Trust
Birkenhead, United Kingdom, CH49 5PE
2
Glan Clwyd Hospital
Bodelwyddan, United Kingdom, LL18 5UJ
3
Darent Valley Hospital
Dartford, United Kingdom
4
Royal Devon and Exeter NHS Trust
Exeter, United Kingdom, EX2 5DW