Status:
COMPLETED
Losartan and Emotional Memory
Lead Sponsor:
University of Oxford
Conditions:
Memory
Learning
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This study explores the effects of single-dose losartan (50mg) versus identical placebo capsule on emotional memory and learning in healthy volunteers.
Detailed Description
The commonly prescribed antihypertensive drug losartan (brand name: Cozaar; UK licensed for 20 years) targets the renin-angiotensin system - a hormone system regulating blood pressure - by acting as a...
Eligibility Criteria
Inclusion
- willing and able to provide informed consent
- male or Female, aged 18-50
- body mass index (BMI) of 18-30 kg/m2
- fluent English skills
- non- or light-smoker (\< 5 cigarettes a day)
Exclusion
- Female participant who is pregnant or breast-feeding
- CNS-active medication during the last 6 weeks
- Current blood pressure or other heart medication (especially aliskiren or beta blockers)
- Intravascular fluid depletion
- Past or present DSM-IV axis-I diagnosis or suspected diagnosis (from SCID results at screening)
- Alcohol or substance abuse
- First-degree family member with a history of a severe psychiatric disease
- Impaired liver or kidney function
- Lifetime history of epilepsy or other neurological disease, systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.
- Insufficient English skills
- participated in another study involving CNS-active medication during the last 6 weeks
Key Trial Info
Start Date :
March 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 28 2018
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT03763409
Start Date
March 1 2018
End Date
September 28 2018
Last Update
December 6 2018
Active Locations (1)
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1
Department of Psychiatry, University of Oxford
Oxford, United Kingdom, OX37JX