Status:
COMPLETED
Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO
Lead Sponsor:
Medical University of Vienna
Conditions:
ARDS
Acute Lung Injury
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
The acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure, presented in 10% of all intensive care patients and carrying a high mortality rate. Extracorporeal membra...
Detailed Description
The aim of this study is to assess the effect of a rigorous low breathing frequency and ultra-low tidal volume ventilation strategy on clinical outcome, compared to standard ventilator settings follow...
Eligibility Criteria
Inclusion
- Moderate to severe ARDS - Partial pressure of oxygen/Fraction of inspired oxygen (PaO2/FiO2) \< 200 mmHg
- ECMO \< 24 hours in situ
- Gender-matched
- Age-matched
Exclusion
- BMI \> 40
- Expected weaning of ECMO \< 3 days (postoperative ECMO)
- Combustion
- Restrictive chest wall impairment
- Pregnancy
Key Trial Info
Start Date :
November 6 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2021
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT03764319
Start Date
November 6 2018
End Date
August 1 2021
Last Update
April 17 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical University of Vienna - Division of General Anaesthesia and Intensive Care Medicine
Vienna, Austria, Austria, 1090