Status:

COMPLETED

Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes.

Lead Sponsor:

Tampere University Hospital

Collaborating Sponsors:

Turku University Hospital

Oulu University Hospital

Conditions:

Diabetic Pregnancy

Insulin Resistance

Eligibility:

FEMALE

Phase:

PHASE4

Brief Summary

The study investigates whether additional metformin medication in combination with regular insulin treatment will decrease the need of insulin for women with diabetes mellitus type 1 during pregnancy.

Detailed Description

Insulin resistance during pregnancy of diabetes mellitus type 1 patients (DM1) increases the need for insulin and makes it more difficult to maintain normoglycemia. Fetal exposure to hyperglycemia ind...

Eligibility Criteria

Inclusion

  • a pregnancy of a woman with type 1 diabetes.

Exclusion

  • multiple pregnancy, significant underlying disease (hearth disease, kidney transplant, IBD (inflammatory bowel disease ), SLE (systemic lupus erythematosus ), diseases with use of high dosage corticosteroids (severe asthma or rheumatic disease), severe complications of diabetes (nephropathy, neuropathy, gastroparesis or severe retinopathy), substance abuse, smoking, BMI \<18, strong early pregnancy nausea (=hyperemesis)

Key Trial Info

Start Date :

August 5 2019

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 19 2022

Estimated Enrollment :

101 Patients enrolled

Trial Details

Trial ID

NCT03765359

Start Date

August 5 2019

End Date

December 19 2022

Last Update

June 7 2023

Active Locations (5)

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Page 1 of 2 (5 locations)

1

Helsinki University Hospital

Helsinki, Finland

2

Central Finland Health Care District

Jyväskylä, Finland

3

Oulu University hospital

Oulu, Finland

4

Tampere University Hospital

Tampere, Finland