Status:
UNKNOWN
Pharmacokinetics in Extracorporeal Membrane Oxygenation
Lead Sponsor:
China-Japan Friendship Hospital
Conditions:
Extracorporeal Membrane Oxygenation
Pharmacokinetics
Eligibility:
All Genders
18-70 years
Brief Summary
The main purpose of the present study is to investigate the risk factors that affect drug pharmacokinetic (PK) during extracorporeal membrane oxygenation (ECMO). To advance understanding of PK varianc...
Detailed Description
Ex vivo experiments for drug stability testing and ECMO circuits testing in animal models.PK studies in healthy animals and critically ill animal models with or without ECMO to define the PK alteratio...
Eligibility Criteria
Inclusion
- Patients who are undergoing ECMO for respiratory and or cardiac dysfunction
- Clinical indication for the antibiotics
- Clinical indication for the sedatives and analgesics
Exclusion
- No consent
- Known allergy to study drug
- Pregnancy
- Massive fluid resuscitation (\>50% blood volume transfused) in the previous 8 hours.
- Therapeutic plasma exchange in the preceding 24 hours
Key Trial Info
Start Date :
September 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2021
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03766282
Start Date
September 1 2017
End Date
December 30 2021
Last Update
December 6 2018
Active Locations (1)
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1
China-Japan Friendship hospital
Beijing, Beijing Municipality, China, 100028