Status:
COMPLETED
Trauma as a Trigger for Autoimmunity
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Autoimmunity
Eligibility:
All Genders
18+ years
Brief Summary
To analyse the immunological reaction to Trauma (pertrochanteric femoral fracture with consequent osteosynthesis) in the first weeks up to one year postoperatively with focus on the development of aut...
Detailed Description
This project represents a unique study of the influence of trauma on the immune system. It addresses the question whether an excess of apoptotic/necrotic cells can induce an at least transient autoimm...
Eligibility Criteria
Inclusion
- pertrochanteric femoral fracture (≤7 days)
- planned gamma nail osteosynthesis
- ability to give written informed consent
Exclusion
- Severe hepatic and renal failure
- current active oncological disease
- current immunosuppressive or biological therapy
- known systemic autoimmune disease
- foreseeable lack of complete follow-up (e.g. due to generally poor health)
- cognitive impairment (delirium, dementia, alteration of consciousness)
- insufficient knowledge of project language
- pregnancy
Key Trial Info
Start Date :
July 4 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2020
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03767712
Start Date
July 4 2016
End Date
January 31 2020
Last Update
April 7 2020
Active Locations (1)
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1
University Hospital Basel
Basel, Switzerland, 4031