Status:
COMPLETED
The Effect of Acute Minocycline Administration on Emotional Processing and Cognition in Healthy Volunteers
Lead Sponsor:
University of Oxford
Conditions:
Mood
Cognitive Change
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
There is growing interest in the possibility of producing more effective antidepressant treatments that target a wider range of pathways involved in depression, including anti-inflammatory and anti-gl...
Detailed Description
Current antidepressant treatments, which largely target monoamine pathways, are efficacious in treating many aspects of major depression, however it is estimated that more than 30% of depressed patien...
Eligibility Criteria
Inclusion
- Participants are willing and able to give informed consent for participation in the study
- Male or female, aged between 18 and 55
- Body mass index (BMI) within the range of 19 - 30 kg/m2
- Sufficiently fluent in English to understand the tasks and instructions
- Female subjects must be outside of their pre-menstrual week on the testing day
Exclusion
- Current or past history of any psychiatric disorder (e.g. depression, anxiety)
- Any medical contra-indication (for example hepatic impairment)
- Current use of any medication which, in the opinion of the study physician, will interfere with minocycline or cause any contraindications
- Known hypersensitivity to tetracyclines or to any of the excipients in minocycline capsules
- Steroidal or non-steroidal anti-inflammatory medication within preceding 2 weeks, including aspirin and ibuprofen
- Congenital or acquired immune deficiency (including participants receiving immunosuppressive or antimitotic drugs)
- Current pregnancy or breastfeeding
- Current substance misuse
- Recent (\< 3 months) use of psychotropic drugs
- Participant in a psychological or medical study involving the use of medication within the last 3 months
- Participant in another study using the same / a similar battery of cognitive / emotional tasks in the last 3 months
- Current smoker of more than 5 cigarettes per day
- Dyslexia (given the nature of the computer tasks)
- Lactose intolerance (placebo is composed of lactose capsules)
Key Trial Info
Start Date :
April 26 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 25 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03768557
Start Date
April 26 2017
End Date
October 25 2018
Last Update
April 18 2019
Active Locations (1)
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1
Warneford Hospital
Oxford, Oxfordshire, United Kingdom, OX3 7JX