Status:
UNKNOWN
SyncAV Study: Investigation of the Efficacy of the SyncAV Fusion Pacing Algorithm on Exercise
Lead Sponsor:
University of Oxford
Conditions:
Heart Failure, Systolic
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In patients with weak pumping function of the heart, uncoordinated contraction of the chambers can be corrected using a cardiac resynchronization therapy ("CRT") pacemaker. These devices make patients...
Detailed Description
Heart failure represents a significant health problem, with the last national heart failure audit demonstrating prevalence in the United Kingdom of 900,000 patients, accounting for 5% of all acute hos...
Eligibility Criteria
Inclusion
- Age ≥18 and able to give informed consent.
- Patients with existing cardiac resynchronization therapy ("CRT") devices able to utilise the SyncAV algorithm, implanted ≥6 months and under follow up at Oxford University Hospitals National Health Service ("NHS") Foundation Trust.
- Evidence of response to CRT, defined as functional improvement or left ventricular ("LV") remodelling on imaging.
- Sinus rhythm and PR interval \<250ms.
- Able to exercise to perform cardiopulmonary exercise testing ("CPET").
Exclusion
- Pregnancy or breast feeding.
- Atrial fibrillation or atrial tachycardia.
- Underlying 2nd or 3rd degree heart block.
- PR interval ≥250ms.
- Chronotropic incompetence, defined as use of rate-response algorithm or ≥80% atrial pacing.
- Any concurrent condition contraindicating use of CPET.
Key Trial Info
Start Date :
May 31 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT03768804
Start Date
May 31 2019
End Date
December 1 2021
Last Update
November 17 2020
Active Locations (1)
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1
Department of Physiology, Anatomy and Genetics, University of Oxford
Oxford, Oxfordshire, United Kingdom, OX1 3PT