Status:
UNKNOWN
The Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and Diabetes
Lead Sponsor:
Chinese PLA General Hospital
Conditions:
Coronary Heart Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
In this study, simvastatin combined with Ezeimebum was used to enhance lipid reduction, and IVUS was used to evaluate the volume and composition of coronary plaque before and after treatment. The aim ...
Detailed Description
This study was conducted in patients with stable angina pectoris complicated with diabetes mellitus in Chinese PLA General Hospital and coronary arteriography confirmed as critical lesion of coronary ...
Eligibility Criteria
Inclusion
- patients aged 18-75 years
- consistent with the Chinese criteria for the diagnosis of chronic stable angina pectoris, stable angina pectoris symptoms in the last three months, and no more than CCS grade 3 of angina pectoris
- coronary angiography showed that the degree of coronary artery stenosis was 50% and 70%
- LDL-C standard: LDL-C \> 80 mg/dL (2.08 mmol/L)
- The patients diagnosed with type 2 diabetes were currently using hypoglycemic drugs or insulin
- Sign the informed consent to join the group.
Exclusion
- Acute coronary syndromes such as myocardial infarction, unstable angina pectoris, variant angina pectoris, cardiac shock, chronic heart failure, malignant arrhythmia, etc.
- Patients requiring stent implantation had been treated with intensive statins prior to admission (e.g. doses of Atto vastatin 40mg or resuvastatin 20mg)
- There were contraindications or statins for statin lowering lipids or statins, and there was a history of adverse reactions (liver injury, rash, myolysis, etc.) in the use of Ezeimebum, etc.
- Severe liver and kidney dysfunction, creatinine clearance \< 30ml / min, acute pancreatitis, malignant tumor, etc.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2019
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT03771053
Start Date
January 1 2018
End Date
December 31 2019
Last Update
December 10 2018
Active Locations (1)
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1
Chinese People's Liberation Army General Hospital
Beijing, Beijing Municipality, China, 100853