Status:
COMPLETED
The Efficacy of Computerized Cognitive Remediation Therapy for Chronic Schizophrenia
Lead Sponsor:
Shanghai Mental Health Center
Conditions:
Schizophrenia
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
The study group received antipsychotic drugs combined with Computerized Cognitive Remediation Therapy (CCRT) for 4 times/week for 45 minutes each time. The control group only received antipsychotic dr...
Detailed Description
Among the cognitive disorders of chronic schizophrenia, the most reported is the executive dysfunction of the prefrontal lobe. There is increasing evidence that Computerized Cognitive Remediation Ther...
Eligibility Criteria
Inclusion
- Age 18-45 years old, Han nationality, male or female;
- Comply with the American Diagnostic Criteria for Mental Disorder (DSM-V) diagnostic criteria for "schizophrenia";
- The course of the disease and continued treatment with antipsychotic drugs for \> 2 years, stable for at least one month;
- Positive NegativeSyndrome Scale (PANSS) \< 70 points;
- intelligence quotient (IQ)\>80;
- Cultural, social and educational backgrounds are sufficient to understand informed consent and research content.
Exclusion
- Concomitant diagnosis in addition to Diagnostic and Statistical Manual of Mental Disorders-V other than schizophrenia;
- Central nervous system organic diseases;
- There are alcohol or other substances dependent or abused in the past two months, causing significant social and cognitive impairment;
- In the past year, there have been major life events such as widowhood;
- Those who have serious suicide attempts (the third item of the (Hamilton Depression Scale-17,HAMD-17) scale "suicide" ≥ 3 points);
- The current patient's severe unstable physical disease;
- pregnant women and lactating women;
- Those who have received modified electroconvulsive therapy (MECT) and repetitive Transcranial Magnetic Stimulation (rTMS) treatment in the past month;
- Those who have been ineffective for more than 3 months of systemic psychotherapy.
Key Trial Info
Start Date :
January 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2021
Estimated Enrollment :
154 Patients enrolled
Trial Details
Trial ID
NCT03772951
Start Date
January 10 2019
End Date
March 31 2021
Last Update
January 11 2022
Active Locations (1)
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1
Huangpu District Mental Health Center
Shanghai, Shanghai Municipality, China, 20000