Status:
COMPLETED
Dyspnea Assessment in Hemodialysis Patients
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Dyspnea; Uremic
End Stage Renal Disease
Eligibility:
All Genders
18+ years
Brief Summary
Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to det...
Detailed Description
Rationale: The available evidence suggest that End-Stage Renal Disease (ESRD) and hemodialysis (HD) have harmful effects on the lungs; the investigators hypothesize that these recurring pulmonary ins...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age equal to or greater than 18 years.
- Dialysis vintage equal to or greater than 3 months.
- Exclusion Criteria
- Smoking history of more than 10 packs/year.
- Active tobacco and/or cannabis smoking.
- Diagnosed chronic pulmonary disease.
- Severe heart failure (NYHA class IV)
- Active infection (including tuberculosis) or malignancy.
- Pregnancy.
- Inability to give consent or understand written information.
- Peripheral oxygen saturation (by pulse oxymetry) dropping below 80% when performing a 12-seconds breathhold.
- Inability to perform spirometry or plethysmography maneuvers.
- Inability to tolerate MRI due to patient size and/or known history of claustrophobia.
- Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants.).
Exclusion
Key Trial Info
Start Date :
March 29 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 25 2020
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT03773991
Start Date
March 29 2019
End Date
February 25 2020
Last Update
August 15 2024
Active Locations (1)
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1
London Health Sciences Centre
London, Ontario, Canada