Status:
UNKNOWN
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance
Lead Sponsor:
Karina Vejrum Sørensen
Conditions:
Type 2 Diabetes Mellitus
Obesity
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Agonistic activation of fat metabolite responsive G-protein-coupled receptors (GPCR) has been linked to improved glucose metabolism through increased glucose-stimulated-insulin-secreting (GSIS) and in...
Detailed Description
During the last decade, several G protein-coupled receptors (GPCR) that respond to dietary lipid metabolites including free fatty acids (FFAs) have been discovered. These receptors have been implicate...
Eligibility Criteria
Inclusion
- body mass index (BMI) of 27.5-40 kg/m2, normal glucose tolerance (two hours OGTT plasma glucose ≤ 7.8 mmol/l), normal blood pressure and normal screening blood samples (kidney and liver function, lipids and hematology) and written informed consent -
Exclusion
- any chronic disease including past gastrointestinal diseases or gastrointestinal surgery, first degree relatives with diabetes, food allergies of relevance, need for prescriptive medicine, smoking, body weight changes (\> 3 kg within three month prior), intake of dietary supplements (\<1 month prior) or any type of restrictive diet for example calorie restriction, vegan diet etc.
- \-
Key Trial Info
Start Date :
June 11 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2018
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03774095
Start Date
June 11 2018
End Date
December 30 2018
Last Update
December 14 2018
Active Locations (1)
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1
Odense University Hospital
Odense, Denmark, 5000