Status:
TERMINATED
Determinants of the Vascular Response to Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
Lead Sponsor:
University Hospital, Montpellier
Collaborating Sponsors:
University Hospital, Paris
Conditions:
COPD Patients
Healthy
Eligibility:
All Genders
35-85 years
Phase:
NA
Brief Summary
Vascular comorbidities constitute a major burden in COPD patients. The atherosclerosis process is preceded by the onset of an endothelial dysfunction (assessed by the flow-mediated dilatation (FMD)), ...
Eligibility Criteria
Inclusion
- A/ COPD patients
- age between 35 and 85 years old
- spirometry showing an FEV1/VC \< lower limit of normal
- with an indication for a pulmonary rehabilitation program
- written and informed consent for this study signed by the patient
- B/ Healthy subjects
- age between 35 and 85 years old
- no cardiovascular or respiratory disease
- normal spirometry
Exclusion
- Unstabilized comorbidity
- Subject in a period of exclusion relative to another protocol
- Major protected by law
- Subject participating in another research protocol
- Subject not affiliated to a social security scheme
- Pregnant or lactating woman
- Patient deprived of freedom by court or administrative order
Key Trial Info
Start Date :
February 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 20 2024
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT03774238
Start Date
February 20 2019
End Date
November 20 2024
Last Update
September 30 2025
Active Locations (2)
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1
CHU Montpellier and CHU Nimes
Montpellier, France, 34295
2
University Hospital, Paris
Paris, France, 75015