Status:
UNKNOWN
Vascular Functions in Myeloma Patients During Anti-tumor Therapy
Lead Sponsor:
University Hospital, Essen
Conditions:
Cardiooncology
Myeloma
Eligibility:
All Genders
18+ years
Brief Summary
Treatment options for multiple myeloma have increased significantly over the last years with the approval of immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). These therapies have marked...
Detailed Description
Treatment options for multiple myeloma have increased significantly over the last years with the approval of immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). These therapies have marked...
Eligibility Criteria
Inclusion
- Included in the study are myeloma patients with planned bortezomib, carfilzomib and lenalidomide-based chemotherapy and 20 subjects from a healthy normal population.
- Age ≥ 18 years
- written consent
Exclusion
- Severe pulmonary, valvular, or congenital heart disease with clinical dyspnoea symptoms
- Life expectancy less than 6 months
- Unstable angina pectoris or indication for coronary revascularization
- Valvular disease (aortic valve and mitral regurgitation greater than moderate, and aortic valve or mitral valve stenosis greater than moderate)
- Atrial fibrillation or flutter
- Chronic renal insufficiency (Cockcroft-Gault GFR \<30 mL / min)
- Severe cirrhosis (Child-Pugh B and C)
- Current or future indication for therapy with organic nitrates
- Leading non-cardiac cause of clinical dyspnea symptoms, such as high-grade obesity or lung disease in need of glucocorticoid therapy or oxygen therapy
- Other cause of clinical dyspnea symptoms, such as high-grade obesity or lung disease with need for glucocorticoid therapy or oxygen therapy
Key Trial Info
Start Date :
December 28 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 28 2020
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT03776331
Start Date
December 28 2018
End Date
March 28 2020
Last Update
December 19 2018
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