Status:
UNKNOWN
Transient Elastography (FibroTouch) for Assessing Risk of Gastroesophageal Varices Bleeding in Compensated Cirrhosis (Pan-CHESS1801)
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Collaborating Sponsors:
Beijing Tsinghua Changgeng Hospital
LanZhou University
Conditions:
Compensated Liver Cirrhosis
Gastroesophageal Varices Bleeding
Eligibility:
All Genders
18-75 years
Brief Summary
Gastroesophageal varices occurs in approximately half of the patients with liver cirrhosis. Variceal bleeding is the most common lethal complication directly from cirrhotic portal hypertension. The go...
Detailed Description
Gastroesophageal varices occurs in approximately half of the patients with liver cirrhosis. Variceal bleeding is the most common lethal complication directly from cirrhotic portal hypertension. The go...
Eligibility Criteria
Inclusion
- age 18-75 years;
- confirmed liver cirrhosis based on liver biopsy or clinical findings;
- compensated liver cirrhosis;
- scheduled to undergo esophagogastroduodenoscopy;
- estimated survival time\> 24 months, and model for end-stage liver disease (MELD) score\< 19;
- with written informed consent.
Exclusion
- contradictions for esophagogastroduodenoscopy;
- body mass index\> 35 kg/m2;
- presence of decompensation events (e.g. ascites, variceal bleeding, hepatic encephalopathy, etc.);
- previous esophageal variceal banding legation or transjugular intrahepatic portosystemic shunt;
- current use of non-selective beta-blockers;
- with portal vein thrombosis or hepatocellular carcinoma;
- non-cirrhotic portal hypertension;
- pregnancy or unknown pregnancy status.
Key Trial Info
Start Date :
December 14 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 13 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03778775
Start Date
December 14 2018
End Date
March 13 2022
Last Update
August 17 2021
Active Locations (16)
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1
The Seventh Medical Center of Chinese PLA General Hospital
Beijing, Beijing Municipality, China, 100000
2
The Fifth Medical Center of Chinese PLA General Hospital
Beijing, Beijing Municipality, China, 100039
3
Beijing Tsinghua Changgung Hospital of Tsinghua University
Beijing, Beijing Municipality, China, 102218
4
The First Hospital of Lanzhou University
Lanzhou, Gansu, China