Status:
RECRUITING
TCR-T Cell Immunotherapy of Lung Cancer and Other Solid Tumors
Lead Sponsor:
Second Affiliated Hospital of Guangzhou Medical University
Collaborating Sponsors:
Tcell Immune (Guangzhou) Science and Technology Ltd.
Conditions:
Nonsmall Cell Lung Cancer
Solid Tumor, Adult
Eligibility:
All Genders
18-75 years
Phase:
PHASE1
Brief Summary
Tumor organoids and TILs (and/or peripheral T cells) cultures will be established from fresh tissure of lung cancer and other solid tumors. Coculture will be utilized to screen tumor-responsive T cell...
Detailed Description
1. Choose appropriate patients with KK-LC-1 expression in advanced lung cancer or other solid tumors and matched MHC-A11 typing, with written consent for this study; For cancer without expression of K...
Eligibility Criteria
Inclusion
- patients with advanced lung tumor or other solid tumor where biopsy is obtainable
- Life expectancy \>12 weeks
- Child-Pugh-Turcotte score \<7
- Adequate heart,lung,liver,kidney function
- Available autologous transduced T cells with greater than or equal to 20% expression of targeted TCR sequences determined by flow-cytometry and killing of tumor cells greater than or equal to 20% in cytotoxicity assay
- Informed consent explained to, understood by and signed by patient/ guardian. Patient/guardian given copy of informed consent. -
Exclusion
- Had accepted gene therapy before;
- Tumor size more than 25cm;
- Severe virus infection such as HBV, HCV, HIV, et al
- Known HIV positivity
- History of lung transplantation
- Active infectious disease related to bacteria, virus,fungi,et al
- Other severe diseases that the investigators consider not appropriate;
- Pregnant or lactating women
- Systemic steroid treatment (greater than or equal to 0.5 mg prednisone equivalent/kg/day)
- Other conditions that the investigators consider not appropriate.
Key Trial Info
Start Date :
December 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2036
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03778814
Start Date
December 1 2018
End Date
December 30 2036
Last Update
June 25 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Second Affiliated Hospital of Guangzhou Medical University
Guanzhou, Guangdong, China, 51260