Status:
COMPLETED
Study of TRC105 + Paclitaxel/Carboplatin and Bevacizumab in Patients With NSCLC
Lead Sponsor:
Tracon Pharmaceuticals Inc.
Collaborating Sponsors:
University of Alabama at Birmingham
Conditions:
Non Small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This is a single center, open-label, nonrandomized, phase 1b, dose-finding study of TRC105 in combination with standard dose bevacizumab and paclitaxel/carboplatin in treatment-naive patients with sta...
Detailed Description
Bevacizumab is a monoclonal antibody to vascular endothelial growth factor (VEGF) that inhibits angiogenesis and extends survival in non-squamous non-small cell lung cancer (NSCLC) patients when given...
Eligibility Criteria
Inclusion
- Key
- Stage 4 Non-Squamous Cell Lung Cancer that has not been treated previously with systemic chemotherapy or bevacizumab, but may have received prior targeted treatment (e.g., alk1 inhibitor)
- ECOG performance status ≤ 1
- Measurable disease by RECIST
- Key
Exclusion
- Non-small cell lung cancer of squamous histology
- Current treatment on another therapeutic clinical trial
- Patients who have received wide field radiotherapy ≤ 28 days (defined as \> 50% of volume of pelvic bones or equivalent) or limited field radiation for palliation \< 14 days prior to study registration or those patients who have not recovered adequately from side effects of such therapy
- Active bleeding or pathologic condition that carries a high risk of bleeding (e.g. hereditary hemorrhagic telangiectasia). Patients who have been uneventfully anti-coagulated with low molecular weight heparin are eligible.
Key Trial Info
Start Date :
September 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2019
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03780010
Start Date
September 1 2015
End Date
June 1 2019
Last Update
October 28 2019
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