Status:
RECRUITING
Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function
Lead Sponsor:
University of Zurich
Conditions:
Osteoarthritis of Multiple Joints of Ankle or Foot
Healthy
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarth...
Detailed Description
Hundreds of millions of patients worldwide require pain-relieving therapy to maintain an acceptable quality of life. Pain relievers, including non-steroidal anti-inflammatory drugs (NSAIDs) and opioid...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients ≥ 18 years of age, male or female, with a diagnosis of osteoarthritis or healthy subjects ≥ 18 years of age;
- Written informed consent;
- Exclusion criteria:
- History of hypersensitivity or allergy to any of the study drugs
- Acute coronary syndrome, stroke, transient ischemic attack, cardiac, carotid or other major CV surgery, percutaneous coronary intervention (PCI) or carotid angioplasty within the 3 months prior to Visit 1;
- Coronary or carotid artery disease likely to require surgical or percutaneous intervention within the 3 months after Visit 1;
- Presence of significant endocrine diseases;
- Presence of active acute infectious diseases;
- Known narrow-angle glaucoma;
- Known epilepsy;
- Cimino-shunt operation on both arms;
- Pregnancy, intention thereof during study, lack of sufficient contraception, breastfeeding;
- Drug or alcohol abuse;
Exclusion
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03781544
Start Date
January 1 2019
End Date
December 31 2025
Last Update
May 17 2024
Active Locations (1)
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1
University Heart Center Zurich
Zurich, Switzerland, 8091