Status:
UNKNOWN
When Should Low-dose Aspirin be Resumed After Peptic Ulcer Bleeding?
Lead Sponsor:
Chinese University of Hong Kong
Collaborating Sponsors:
Beijing Friendship Hospital
National Taiwan University Hospital
Conditions:
Aspirin
GastroIntestinal Bleeding
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute upper gastrointestinal (GI) bleeding associated with the use of low-dose aspirin (ASA) is a major cause of peptic ulcer bleeding worldwide. Among survivors of acute myocardial infarction, a stud...
Detailed Description
Acute upper gastrointestinal (GI) bleeding associated with the use of low-dose aspirin (ASA) is a major cause of peptic ulcer bleeding worldwide. Among survivors of acute myocardial infarction, a stud...
Eligibility Criteria
Inclusion
- Age \>18
- Patients with actively bleeding gastroduodenal lesions (peptic ulcer, bleeding erosions, or Dieulafoy's lesion) or ulcers showing other high risk stigmata (visible blood vessels or adherent clots) treated by endoscopic therapy
- Subjects continue to require regular ASA or dual anti-platelet therapy for treatment of CV or cerebrovascular diseases after this bleeding episode
Exclusion
- Patients who received ASA for primary prophylaxis
- Unsuccessful endoscopic hemostasis of bleeding ulcers or ulcer perforation
- Gastric outlet obstruction
- Known sensitivity to PPIs
- Previous partial gastrectomy or vagotomy
- Patients need concomitant anticoagulant
- Pregnant unless sterilization, menopause or last menstrual period within 7 days
- Other co-morbidities or advanced age that will hinder the drug compliance or follow up
- Malignancy on active treatment
- Unable to give consent
Key Trial Info
Start Date :
January 14 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2024
Estimated Enrollment :
436 Patients enrolled
Trial Details
Trial ID
NCT03785015
Start Date
January 14 2019
End Date
February 28 2024
Last Update
October 22 2020
Active Locations (1)
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1
Prince of Wales Hospital
Hong Kong, Hong Kong