Status:
ACTIVE_NOT_RECRUITING
Intestinal Microbiota on Allergy, Growth and Development
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Pregnancy
Eligibility:
FEMALE
18-45 years
Brief Summary
There is growing evidence that microbial programming beginning in-utero can be a central component for a balanced development of innate immunity and optimal growth and development in newborns. However...
Detailed Description
Our unit is one of the centres contributing to the International multicentre HAPO study. We recruited 1760 Chinese pregnant women between 2000 and 2005. The HAPO study investigated whether any adverse...
Eligibility Criteria
Inclusion
- Expectant ethnic Chinese mothers aged 18 - 45 years who are in the first trimester of pregnancy
- Singleton pregnancy
- Plan to give birth in the Prince of Wales Hospital, Hong Kong and stay with the child in Hong Kong for the next 3 years
- Willing to provide serial biological samples for microbiota detection
- Willing for her coming newborn to be prospectively followed up for clinical and microbiota data collection in PWH
- Participate voluntarily and capable of giving informed consent
Exclusion
- Significant medical conditions especially those required long term medications, such as oral steroid, antihypertensive drugs, diabetic medications and lipid-lowering agents, during or before pregnancy
- History of chronic inflammatory or neoplastic diseases involving the gastrointestinal tract (e.g. inflammatory bowel disease, coeliac disease, colorectal cancer)
- Significant pregnancy complications, such as intrauterine foetal demise/stillbirth, extreme prematurity, or pre-labour rupture of membranes before 24 weeks
- Mother with mental incapacity such that they are not able to give informed consent
- Foetal chromosomal or clinically significant structural abnormalities
- The current pregnancy is a conception through either sperm or ovum donation
Key Trial Info
Start Date :
November 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03785093
Start Date
November 1 2018
End Date
June 30 2026
Last Update
September 5 2023
Active Locations (1)
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1
Prince of Wales Hospital
Hong Kong, Hong Kong, China, Hong Kong, Shatin