Status:
UNKNOWN
Predicative Value of Multimodal MRI in Moyamoya Disease
Lead Sponsor:
Chinese PLA General Hospital
Conditions:
Moyamoya Disease
Magnetic Resonance Imaging
Eligibility:
All Genders
Brief Summary
Moyamoya disease (MMD) is a nonatherosclerotic cerebrovascular abnormality, characterized by a progressive stenosis or occlusion of the intracranial internal carotid arteries (ICAs) and their proximal...
Detailed Description
Imaging protocols: 3D TOF 3SLAB; SWAN; 3D ASL 2.0s; T1; T2; T2 Flair; DWI; tASL 2.0s; DCE; APT-CEST Imaging evaluation: 1. Transfer contrast volume value measured by DCE; 2. ASL shows CBF in associ...
Eligibility Criteria
Inclusion
- DSA/MRA shows stenosis or occlusion in the distal internal carotid artery or the proximal portion of anterior/middle cerebral artery;
- Abnormal vascular network appeared in the brain;
- With the onset of cerebral ischemia/hemorrhage/TIA;
- No cerebral infarction or cerebral hemorrhage occurred within the last month;
- All MRI examination performed according to study protocol;
- Signed informed consent obtained from the patient or patient's legally authorized representative;
- Having complete medical history and clinical follow up;
- Imaging data can be processed.
Exclusion
- Patients with moyamoya syndrome secondary to systemic diseases such as arteriosclerosis, sickle cell anemia, radiation therapy, etc.;
- Patients with severe mental disorders such as psychosis, liver and kidney dysfunction, poor blood pressure or blood glucose control, severe depression and substance abuse, low IQ, and acute phase of severe stroke with definite limb dysfunction should also be excluded.
- Pregnancy
Key Trial Info
Start Date :
September 7 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03785171
Start Date
September 7 2018
End Date
September 1 2021
Last Update
December 24 2018
Active Locations (1)
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1
Chinese PLA General Hospital
Beijing, Beijing Municipality, China, 100853