Status:
UNKNOWN
Systematic Evaluation of Protamine Doze in Cardiac Surgery
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Cardiac Surgery With Cardiopulmonary Bypass
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The precise amount of protamine required to neutralize unfractionated heparin (UFH) remains unknown. This study will systematically identify the doze needed to neutralize UFH following cardiopulmonary...
Detailed Description
The precise dose of protamine needed to neutralize unfractionated heparin (UFH) is unknown. Research suggests that low dose protamine is associated with decreased need for transfusions in cardiac surg...
Eligibility Criteria
Inclusion
- Elective cardiac surgery patients \> 18 years age who can provide written consent for the study.
Exclusion
- History of any known coagulopathies, liver dysfunction, previous cardiac surgery, preoperative abnormal coagulation profiles, recent exposure to heparin (unfractionated or low molecular weight), warfarin, clopidogrel or other direct thrombin inhibitors in the preceding 7 days.
- History of heparin resistance
- History of adverse reactions to protamine
- Patients identified as having heparin resistance
- Anticipated CPB time \> 2-2.5 hrs
Key Trial Info
Start Date :
September 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2020
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03787641
Start Date
September 20 2018
End Date
February 28 2020
Last Update
December 31 2018
Active Locations (1)
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1
London Health Sciences Centre
London, Ontario, Canada, N6A 5A5