Status:

COMPLETED

Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation

Lead Sponsor:

Vanderbilt University Medical Center

Conditions:

Acute Respiratory Failure

Intubation Complication

Eligibility:

All Genders

18+ years

Phase:

PHASE4

Brief Summary

Complications are common during tracheal intubation of critically ill patients. Nearly one in five patients undergoing intubation in the intensive care unit experiences cardiovascular collapse, define...

Detailed Description

The PREPARE II trial is a prospective, parallel group, pragmatic, randomized trial comparing the effect of a preintubation fluid bolus to no preintubation fluid bolus on the incidence of cardiovascula...

Eligibility Criteria

Inclusion

  • Patient is undergoing endotracheal intubation in a participating unit
  • Planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit
  • Patient is at least 18 years of age
  • Administration of sedation is planned (with or without neuromuscular blockade)
  • Positive pressure ventilation between induction and laryngoscopy is planned (e.g., non-invasive ventilation or bag-mask ventilation)

Exclusion

  • Prisoners
  • Pregnant patients
  • Urgency of intubation precludes safe performance of study procedures
  • Operator feels administration of a fluid bolus is indicated or contraindicated for the safe performance of the procedure

Key Trial Info

Start Date :

February 1 2019

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

June 21 2021

Estimated Enrollment :

1067 Patients enrolled

Trial Details

Trial ID

NCT03787732

Start Date

February 1 2019

End Date

June 21 2021

Last Update

August 12 2021

Active Locations (11)

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Page 1 of 3 (11 locations)

1

University of Alabama at Birmingham

Birmingham, Alabama, United States, 35233

2

Louisiana State University School of Medicine

New Orleans, Louisiana, United States, 70112

3

Ochsner Medical Center | Ochsner Health System

New Orleans, Louisiana, United States, 70121

4

Lahey Hospital & Medical Center

Burlington, Massachusetts, United States, 01805