Status:
RECRUITING
Ischemic Postconditioning in STEMI Patients Treated With Primary PCI
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
ST Segment Elevation Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart...
Detailed Description
Myocardial reperfusion with the use primary percutaneous coronary intervention (PCI) is effective, but restoration of blood flow may itself jeopardize the myocardium, a phenomenon known as reperfusion...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Acute onset of chest pain with \< 12 hours duration
- STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI.
- TIMI flow 0-1 in infarct related artery
Exclusion
- Potential pregnancy
- Refusal to participate
- OHCA without subsequent consciousness despite ROSC
- Thrombectomy considered unavoidable
Key Trial Info
Start Date :
February 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2033
Estimated Enrollment :
1800 Patients enrolled
Trial Details
Trial ID
NCT03787745
Start Date
February 4 2019
End Date
January 31 2033
Last Update
November 28 2023
Active Locations (1)
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1
The Heart Center, Rigshospitalet, University of Copenhagen
Copenhagen, Denmark, 2100