Status:
COMPLETED
Impact of Periodontal Treatment on the RANKL/OPG Ratio in Crevicular Fluid
Lead Sponsor:
University of Valencia
Conditions:
Periodontal Diseases
Biomarkers
Eligibility:
All Genders
40-60 years
Brief Summary
Objectives: Alveolar resorption is one of the most important events in periodontitis. Osteoclast activity is regulated by the ratio between receptor activator of NF-κB ligand (RANKL) and osteoproteger...
Detailed Description
Material and methods Study design A case-control study was proposed. A group of periodontally healthy subjects was compared to a group of patients with periodontitis before and after scaling and root ...
Eligibility Criteria
Inclusion
- -The control group included:
- 10 periodontally healthy subjects
- Without signs or symptoms of periodontal disease.
- -The study group included:
- 15 subjects diagnosed with mild or advanced chronic periodontitis.
- One non-affected single-rooted tooth (healthy site)
- Single-rooted tooth with periodontitis (periodontitis site) with the following features: with clinical attachment loss equal to or greater than 6 mm and bleeding upon probing.
Exclusion
- Subjects with aggressive periodontitis
- Systemic diseases or consumption of drugs affecting bone metabolism
- Antibiotic, anti-inflammatory or contraceptive treatment for the last three months prior to study initiation
- Antiplatelet therapy for the last 7 days prior to study onset
- Primary or secondary occlusal trauma
- Periapical or periodontal abscess in some of the teeth included in the study
- Periodontal treatment within the last 6 months
- Orthodontic treatment
- Smoking
- Pregnant or breastfeeding.
Key Trial Info
Start Date :
February 2 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 6 2016
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03787875
Start Date
February 2 2016
End Date
November 6 2016
Last Update
December 26 2018
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.