Status:
UNKNOWN
High Flow Nasal Cannula Versus Non-invasive Ventilation in Prevention of Escalation to Invasive Mechanical Ventilation in Patients With Acute Hypoxemic Respiratory Failure
Lead Sponsor:
Assiut University
Conditions:
Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Oxygen therapy is first-line treatment in the management of acute respiratory failure (ARF). Different oxygen devices have become available over recent decades, such as low-flow systems (nasal cannula...
Detailed Description
Oxygen therapy is the first-line treatment in management of acute respiratory failure (ARF). Different oxygen delivery devices have become available over recent decades, either low-flow systems (nasal...
Eligibility Criteria
Inclusion
- Participants admitted to the RICU with acute hypoxemic respiratory failure requiring NIV support with the following criteria:
- RR\> 25 breath/minute
- Use of accessory muscles of respiration, paradoxical breathing, thoracoabdominal asynchrony.
- Hypoxemia evidenced by PaO2 / FiO2 ratio \<300
Exclusion
- Patients who have any of the following:
- I. Indication for emergency endotracheal intubation. II. HR \<50 beat\\minute with decreased level of consciousness III. Persistent hemodynamic instability with
- Systolic blood pressure \<90 mmHg after infusing a bolus of crystalloid solution at a dose of 30 ml / kg
- life-threatening arrhythmia. IV. Undrained pneumothorax or Pneumothorax with persistent air leak. V. Extensive facial trauma or burn VI. Refusal to participate. VII. Usual long-term treatment with NIV for chronic disease VIII. Altered mental status with decreased consciousness and/or evidence of inability to understand .
- IX. Tracheotomy or other upper airway disorders X. Active upper gastrointestinal bleeding
Key Trial Info
Start Date :
May 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03788304
Start Date
May 1 2019
End Date
December 1 2020
Last Update
October 21 2019
Active Locations (1)
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1
Assiut University hospital
Asyut, Egypt, assiut University 71515