Status:
UNKNOWN
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar
Lead Sponsor:
Jordan University of Science and Technology
Collaborating Sponsors:
McGill University
InterPharma One LLC
Conditions:
Operation Site Inflammation
Pain, Postoperative
Eligibility:
All Genders
18-50 years
Phase:
PHASE2
PHASE3
Brief Summary
Clinical and preclinical studies have demonstrated encouraging results of non-steroidal anti-inflammatory drug (NSAID) chronotherapy in the management and treatment of inflammatory diseases such as rh...
Detailed Description
Introduction and background: The surgical extraction of wisdom teeth under local anesthesia is one of the most common oral surgical procedures (1). Ten million third molars (wisdom teeth) are extract...
Eligibility Criteria
Inclusion
- (i) be aged between 18 and 35 years old
- (ii) be healthy according to the American Society of Anesthesiologists (ASA) classification (subject should not have an active infection, trismus, hyperthermia, or swelling before surgery and must be able to maintain adequate oral hygiene)
- (iii) have an adequate understanding of written and spoken English or Arabic to fill out a questionnaire,
- (iv) be capable of signing an informed consent form
- (vi) third molar surgical extraction, the indicated teeth should be lower third molars and partially or completely impacted
Exclusion
- (i) have a history of systemic diseases (e.g., diabetes mellitus, hypertension, gastric ulcer)
- (ii) have a severe/serious illness that requires frequent hospitalization
- (iii) are current smokers
- (iv) are pregnant or breastfeeding
- (v) are taking antinflammtory or analgesic drugs in the previous two weeks or are allergic to NSAIDs
- (vi) have impaired cognitive or motor function
- (vii) are unable to return for evaluations/study recalls.
Key Trial Info
Start Date :
April 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT03789058
Start Date
April 19 2018
End Date
December 1 2022
Last Update
August 30 2021
Active Locations (1)
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1
Jordan University of Science and Technology
Irbid, Jordan