Status:
COMPLETED
Exploring the Relationship Between Brain Asymmetry and Attention
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Normal Physiology
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
Background: People tend to pay more attention to one side of space than the other and this may be due to differences in the structure and function of the two sides of the brain. We are interested in ...
Detailed Description
Objective The goal of this protocol to explore correlations between lateralized individual differences in visual attentional preference and hemispheric asymmetries in functional connectivity between ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age 18 and older
- Able to provide consent
- For some sub-studies, we may limit participation by handedness or eye dominance.
- EXCLUSION CRITERIA:
- Any current major neurological or psychiatric disorder, such as, (but not limited to) stroke, Parkinson disease, Alzheimer disease, schizophrenia or major depression
- Findings on neurological examination indicative of significant brain disease
- Individuals with significant health problems, such as cardiovascular disease, malignancy, or connective tissue disorder
- History of seizure, defined as a diagnosis by a health care provider of one or more epileptic seizures or an anecdotal history which, in the opinion of the PI, is suggestive of epileptic seizure. Any individual who answers other than negatively to the question, Have you ever had an epileptic seizure on screening will be questioned directly by the PI
- Current oral use of a medication that lowers the seizure threshold such as neuroleptics, beta lactams, isoniazid, metronidazole, tricyclic or other antidepressants, or prescription stimulants
- Individuals regularly taking medications that cause significant psychomotor activation or depression, e.g., stimulants and CNS depressant drugs such as benzodiazepines, will be excluded.
- For MRI studies: Any metal in the body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, any individual who was a welder or metal worker. Participants will also be excluded if they are uncomfortable in small closed spaces (i.e. claustrophobia) or are not able to lie comfortably on their back for up to two hours
- Pregnancy or plans to become pregnant in the next two months
- Members of the Behavioral Neurology Unit, NINDS
- Use of illegal drugs in the past year
- Consumption of more than 7 alcoholic drinks a week for females or 14 alcoholic drinks a week for males.
- There is no general exclusion for NIH employees. Inclusion/exclusion criteria will be checked before enrollment in each sub-study to ensure that participants remain eligible.
Exclusion
Key Trial Info
Start Date :
February 28 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 24 2022
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT03789201
Start Date
February 28 2019
End Date
October 24 2022
Last Update
October 26 2022
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892