Status:
UNKNOWN
Fecal Microbiota Transplant (FMT) to Induce Weight Loss in Obese Subjects
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Obesity
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Obesity is associated with changes in the composition of the intestinal microbiota, and the obese microbiome appears to be more efficient in harvesting energy from the diet. Fecal microbiota transpla...
Detailed Description
Recently, accumulating evidence supports a role of the enteric microbiota in the pathogenesis of obesity-related insulin resistance. Obesity is associated with changes in the composition of the intest...
Eligibility Criteria
Inclusion
- Age 18-75; and
- BMI ≥28 kg/m\^2 and \< 45 kg/m\^2; and
- Written informed consent obtained
Exclusion
- Current pregnancy
- Known history or concomitant significant gastrointestinal disorders (including Inflammatory Bowel Disease, current colorectal cancer)
- Known history or concomitant significant food allergies
- Immunosuppressed subjects
- Known history of severe organ failure (including decompensated cirrhosis), kidney failure, epilepsy, acquired immunodeficiency syndrome
- Current active sepsis
- Known contraindications to oesophago-gastro-duodenoscopy (OGD)
- Use of probiotic or antibiotics in recent 3 months
- New drugs in the last three months that can impact on metabolism or body weight
- Previous gastric or small intestinal surgery that alters gut anatomy such as fundoplication, gastric resection, gastric bypass, small bowel resection, ileoectomy, colectomy
- Patients who have a confirmed current active malignancy or cancer
Key Trial Info
Start Date :
December 28 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03789461
Start Date
December 28 2018
End Date
December 1 2022
Last Update
February 14 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Chinese University of Hong Kong
Hong Kong, Hong Kong