Status:
UNKNOWN
Ketamine Versus Propofol Effect on the Immune-mediatory Response for Abdominal Surgery
Lead Sponsor:
Mansoura University Hospital
Conditions:
Major Abdominal Surgery
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Host systemic responses to vigorous stimuli as trauma, surgical tissue injury, anesthesia and post-operative pain, leads to release a variety of pro-inflammatory cytokines including interleukin-1 (IL-...
Detailed Description
The release a variety of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6) mainly from monocytes and macrophages due to surgical traum...
Eligibility Criteria
Inclusion
- Elective major abdominal surgeries with median incision with right or left extension.
- ASA -physical status I -II
- aged from 18 till 70 years
Exclusion
- body mass index more than 35 kg/m2,
- Patients having severe cardiovascular, respiratory, hepatic, renal, Endocrinol disorders, malignant
- Patients having chronic inflammatory diseases
- Patients received suppressant drugs in the 6 weeks before surgery.
- Any known allergy or any contraindications to anesthetic drugs;
- patient refusal,
- The usage of anti- emetic drug 24 hours before operation
Key Trial Info
Start Date :
January 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 15 2019
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT03793075
Start Date
January 10 2019
End Date
August 15 2019
Last Update
January 7 2019
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