Status:
COMPLETED
TARGET-Metabolic Effects
Lead Sponsor:
Australian and New Zealand Intensive Care Research Centre
Collaborating Sponsors:
The Canberra Hospital
Royal Adelaide Hospital
Conditions:
Critical Illness
Enteral Nutrition
Eligibility:
All Genders
18+ years
Brief Summary
The estimation of calorie needs during routine practice in critically ill patients is highly variable and the thermogenic effect of continuous delivery of enteral nutrition (EN) on overall calorie uti...
Eligibility Criteria
Inclusion
- Patients must first meet the inclusion and none of the exclusion criteria for the TARGET main trail (NCT02306746). The following additional criteria applies for this study when indirect calorimetry is being used:
- Within 48 hours of randomisation to TARGET (first measurement only)
- Fi02 \< 50% for the past 1 hour
- Positive end expiratory pressure (PEEP) \< 12 mmHg for the past 1 hour
- The IC test can be conducted within 48 hours of randomisation to TARGET
- The patient is not considered agitated using the usual site assessment
- There is a clinician available to complete the test
Exclusion
- There is an air leak in the ventilation circuit (ie bubbling inter-costal catheters, cuff leak at the endotracheal tube
- The patient is receiving renal replacement therapy or extracorporeal membrane oxygenation at the time of measurement
- Has had surgery in the last 6 hours (if enough time within the 48 hour window, consider waiting until this criteria is less than 6 hours)
- If the patient has a traumatic brain injury, for the previous 6 hours, their intracranial pressures have been unstable and in the opinion of the treating intensivist are not controlled
- The treating clinician believes that the IC test will pose risk to the patient
Key Trial Info
Start Date :
July 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2018
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT03793244
Start Date
July 1 2017
End Date
August 1 2018
Last Update
January 4 2019
Active Locations (1)
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1
ANZIC-RC
Melbourne, Victoria, Australia, 3004