Status:
COMPLETED
The Role of Learning in Nocebo Hyperalgesia
Lead Sponsor:
Leiden University Medical Center
Collaborating Sponsors:
Universiteit Leiden
Conditions:
Nocebo Effects
Hyperalgesia
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
Nocebo effects are adverse effects induced by patients' expectations. Nocebo effects on pain may underlie several clinical conditions, such as chronic pain. These effects can be learned via classical ...
Detailed Description
Main planned analyses: Primary Outcome; Comparing the effectivity of conditioning with PRF, conditioning with CRF, and sham conditioning, in inducing nocebo effects on pain: The magnitude of the ind...
Eligibility Criteria
Inclusion
- Aged 18 - 35 years
- Good understanding of the Dutch language
Exclusion
- Severe or chronic physical morbidity (e.g., heart and lung diseases, diabetes)
- Psychiatric disorders (DSM diagnosis; e.g., depression, autism)
- Chronic pain complaints (≥ 6 months) at present or in the past
- Current pain
- Current use of analgesic medication
- Pregnancy
- After inclusion, participants who do not reach a sensation of high pain with the highest temperature administered or participants who appear unable to distinguish between moderate and high pain stimuli will also be excluded
Key Trial Info
Start Date :
September 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2019
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT03793790
Start Date
September 20 2018
End Date
April 30 2019
Last Update
August 13 2019
Active Locations (1)
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1
Leiden University
Leiden, South Holland, Netherlands, 2333 AL