Status:
COMPLETED
The Dallas Asthma Brain and Cognition (ABC) Study
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
Southern Methodist University
Conditions:
Asthma
Eligibility:
All Genders
40-69 years
Brief Summary
Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequat...
Detailed Description
This study will implement a cross-sectional design, conducted across two sessions. The first session will capture cognitive performance, health history, and relevant social, behavioral, and emotional ...
Eligibility Criteria
Inclusion
- For asthma patients: diagnosis of asthma (verified by a medical documentation) for at least 2 years; for healthy volunteers: no significant medical or psychiatric history.
- Ages 40 to 69 years old.
- Proficient in English.
- Education level of at least 10th grade level.
Exclusion
- Treatment with oral corticosteroids in the previous 6 weeks, because of the potent effects of this drug on airway reactivity.
- Spirometry: Peak expiratory flow (PEF) below 60% of predicted.
- Diagnosis of vocal cord dysfunction (identified by abnormalities in spirometric flow-volume curves), clinically significant chronic obstructive pulmonary disease, or emphysema.
- Presence or history of medical or neurological disorder that may affect brain function and the physiological systems of interest (e.g. angina, myocardial infarction, congestive heart failure, transient ischemic attacks, cerebrovascular accidents, emphysema, or chronic obstructive pulmonary disease, history of seizures or head trauma, endocrine disorders or renal disease, chemotherapy or radiation presently or in the past 5 years, uncontrolled diabetes, blood pressure above 160/90 (self-reported or measured at session 1).
- Corrected vision poorer than 20/30 on Snellen Eye Chart.
- Presence or history of Schizophrenia, Psychosis, Dementia, Bipolar I, Bipolar II, PTSD or Acute Stress Disorder
- Current or recent history (within 1 year) of Substance Related Disorders, current recreational drug use (defined as past 30 days) or consuming more than 20 alcoholic drinks per week.
- Current treatment with anti-psychotics, sedatives, benzodiazepines with a half-life longer than 6 hours.
- Previous electroconvulsive therapy.
- Presence of history of orthopaedic circumstances and metallic inserts interfering with MR scanning (prior surgeries and/or implant pacemakers, pacemaker wires, artificial heart value, brain aneurysm surgery, middle ear implant, non-removable hearing aid or jewelry, braces or extensive dental work, cataract surgery or lens implant, implanted mechanical or electrical device, artificial limb or joint, foreign metallic objects in the body such as bullets, BB's, shrapnel, or metalwork fragments, pregnancy, claustrophobia, uncontrollable shaking, or inability to lie still for one hour.
- Not proficient in English.
- In the opinion of the principal investigator, participant is otherwise unsuitable for this study.
Key Trial Info
Start Date :
February 21 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 28 2025
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT03794856
Start Date
February 21 2019
End Date
May 28 2025
Last Update
July 9 2025
Active Locations (2)
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1
Southern Methodist University
Dallas, Texas, United States, 75206
2
The University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390