Status:
UNKNOWN
Phenotypic and Functional Study of 4BL B Cells in Multiple Sclerosis (MS)
Lead Sponsor:
University Hospital, Lille
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-60 years
Brief Summary
Recent works highlight the B cells involvement in multiple sclerosis (MS) pathology but their role remains poorly understood. It was previously described that activated memory B cells called 4BL due t...
Detailed Description
the aim to compare the proportion of peripheral (blood) 4 BL cells but also 4-BL cells in cerebro spinal fluid (CSF) in MS compared to healthy controls and to other inflammatory neurological disease b...
Eligibility Criteria
Inclusion
- Inclusion Criteria for MS group:
- MS defined by McDonald 2017 criteria with a disease duration of less than 1 year
- between 18 and 60 years old patients
- naïve of any immune therapy or steroid intake
- patients who signed consent to the study
- Inclusion Criteria for controls with inflammatory of non inflammatory neurological disease:
- patients who signed consent to the study
- between 18 and 60 years old patients
- naïve of any steroid intake or immune therapy
- Inclusion criteria for healthy controls:
- control who signed consent at transfusion center for their blood collect to be used for study
- between 18 and 60 years old patients
- naïve of any steroid intake or immune therapy
- Exclusion Criteria:
- pregnancy or breast-feeding
- patients or controls unable to sign the consent or to consent
Exclusion
Key Trial Info
Start Date :
December 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2022
Estimated Enrollment :
172 Patients enrolled
Trial Details
Trial ID
NCT03796611
Start Date
December 1 2020
End Date
October 1 2022
Last Update
September 16 2020
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