Status:
ACTIVE_NOT_RECRUITING
Minimally-invasive Non-surgical and Surgical Periodontitis Treatment
Lead Sponsor:
Queen Mary University of London
Conditions:
Periodontitis
Eligibility:
All Genders
25-70 years
Phase:
NA
Brief Summary
To compare the efficacy of a modified minimally-invasive non-surgical periodontal therapy (MINST) approach with a surgical approach (M-MIST) in determining bone and clinical attachment changes in intr...
Detailed Description
Periodontal diseases are inflammatory conditions that affect the supporting apparatus of the teeth, including gingiva and alveolar bone. The bone loss resulting from periodontitis often is irregular a...
Eligibility Criteria
Inclusion
- Age 25-70
- Diagnosis of 'Periodontitis' stage III or IV (grades A to C)
- Presence of ≥1 'intrabony defect' (PPD, \>5 mm with intrabony defect depth ≥3mm at screening radiograph),
- Signed informed consent. -
Exclusion
- 1\. Smoking (current or in past 5 years) including e-cigarettes/vaping 2. Medical history including diabetes or hepatic or renal disease, or other serious medical conditions or transmittable diseases 3. History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures 4. Antiinflammatory or anticoagulant therapy during the month preceding the baseline exam 5. Systemic antibiotic therapy during the 3 months preceding the baseline exam 6. History of alcohol or drug abuse, 7. Self-reported pregnancy or lactation 8. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that according to the investigator may increase the risk associated with trial participation, 9. Periodontal treatment to the study site within the last 12 months (excluding not-extensive subgingival debridement as judged by the examining clinician).
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Key Trial Info
Start Date :
March 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2025
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT03797807
Start Date
March 20 2019
End Date
December 31 2025
Last Update
June 8 2025
Active Locations (1)
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1
Barts and The London Dental Hospital
London, United Kingdom, E1 2AD