Status:
COMPLETED
Genetic Variants in Nicotinamide Adenine Dinucleotide (NAD) Synthesis Pathway
Lead Sponsor:
Mayo Clinic
Conditions:
Vacterl Association
Congenital Malformation
Eligibility:
All Genders
Brief Summary
Researchers are trying to identify versions of genes as well as factors in subjects blood associated with certain types of congenital malformations(CMs). This study will help the researchers to better...
Eligibility Criteria
Inclusion
- Adults with confirmed or putative diagnosis of VACTERL association;
- Families (mother, father, biological offspring) with a history of VACTERL-associated malformations
- Gravid or non-gravid women with a history of miscarriage and/or offspring with non-VACTERL-associated malformations
- Willingness to abstain from red meat, meat products, chicken, peanuts, or brewer's yeast (including beer) at least 24 hours prior to blood and urine collection
Exclusion
- 1\) Parents of non-biological children 3) Children with congenital malformations associated with an identifiable environmental or lifestyle exposure 4) Children with congenital malformations associated with confirmed chromosomal disorders 5) Failure to abstain from red meat, meat products, chicken, peanuts, or brewer's yeast (including beer) at least 24 hours prior to blood and urine collection.
Key Trial Info
Start Date :
December 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
132 Patients enrolled
Trial Details
Trial ID
NCT03799705
Start Date
December 1 2019
End Date
December 1 2022
Last Update
April 19 2024
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905