Status:
COMPLETED
ONSD and Neurotoxicity in Liver Transplant
Lead Sponsor:
Mansoura University
Conditions:
Liver Transplant; Complications
Eligibility:
All Genders
18-70 years
Brief Summary
This is a diagnostic test accuracy study. The investigators measure optic nerve sheath diameter (ONSD) by ultrasound on the eye during living donor liver transplantation operation at 5 minutes after r...
Detailed Description
Neurotoxicity is mainly associated with tacrolimus and cyclosporin, amounting to 10 - 30% for CS and up to 32% for tacrolimus.(2) . Sirolimus, everolimus, and mycophenolate mofetil lack the neurotoxic...
Eligibility Criteria
Inclusion
- All adult patients of both sex undergoing living donor liver transplantation operation
Exclusion
- History of optic neuritis
- History of Arachnoid cyst of the optic nerve.
- History of eye trauma
- History of optic nerve trauma.
- Familial amylodotic polyneuropathy
- Wilson disease.
- Patient planned to use immunosuppression regimen other than tacrolimus.
Key Trial Info
Start Date :
January 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 23 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03799770
Start Date
January 1 2019
End Date
March 23 2021
Last Update
April 12 2022
Active Locations (1)
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1
Gastroenerology Surgical Center - Liver transplantation program
Al Mansurah, Dakahlia Governorate, Egypt, 35516